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Ketamine Clinic


Ketamine is a legal, safe and effective treatment option for treatment-resistant depression (TRD), major depressive disorder, PTSD, and anxiety.

Evolve's ketamine clinic offers treatment that has the potential to accelerate the healing process in individuals suffering from an array of distressing mental health symptoms.

Since it came on the market as an anesthesia drug in the 1960’s many physicians have observed and reported its antidepressant effects. But we’ve just seen in the last 20 years a resurgence of its use for depression as ketamine clinics have popped up across the nation. It is the first truly new antidepressant in over 30 years, as it works on an entirely different neurotransmitter system, the glutamate system.

Every other antidepressant on the market works on the monoamine system – to enhance serotonin, dopamine, and norepinephrine.

In the early 2000’s that formal studies began looking at the effects of low-dose (subanesthetic) ketamine on depression. Since then there have been hundreds of papers repeating the overall positive effects, demonstrating we in fact do have a new, fast-acting, low side-effect medication for depression, and especially hopeful for treatment-resistant depression.


Your ketamine journey


Set up a Discovery Call


Meet Your Doctors


Begin Your Therapy Sessions


Follow-up Integration



Schedule a Discovery Call with the doctor.


“Ketamine is ‘a time-out from ordinary mind,’ allowing a much needed respite from the psychological exhaustion brought about by depression.”

Ketamine provides a window for change; it is not a “one-shot wonder.” Those who understand this, and view ketamine as a part of their overall treatment plan will have better odds of recovery and remission. It is important to continue therapy, self-care, and integration between ketamine therapy sessions to obtain the most benefit.

It’s important to understand that ketamine is not a cure for depression. It is a catalyst, one that can have rapid and long-lasting effects in some, while others require multiple sessions and require maintenance dosing every few months.

It has been studied for major depressive disorder, bipolar depression, PTSD, OCD, eating disorders and treatment-resistant depression. Ketamine has specifically shown significant promise for treating suicidal ideation. While there are common responses, the character of ketamine (and depression for that matter) is that it’s different for everyone. No clinician should promise you a cure nor will they be able determine how many sessions you will need at the start of treatment. It is important for the patient to understand they are entering a relationship with the medicine and the clinician — they are embarking on a journey of healing wherein they have an active role.


We make it easy for you

Customized treatments

Physician-driven treatment plans using therapy and integrative medicine.

Virtual appointments

Screening and post-treatment consultations available via telemedicine.

Highly trained physicians

Our board certified physicians bring a wealth of knowledge to provide truly integrated medicine.


Frequently asked questions

Do you offer Esketamine (Spravato)?

We do not currently offer Spravato in our clinic. While Spravato is FDA-approved for depression, we choose to not use this form in our practice. Ketamine is FDA-approved as an anesthetic agent and is used off label to treat depression, bipolar depression, post-traumatic stress disorder (PTSD), and substance abuse disorders. Ketamine is currently offered for in office use under medical supervision.

How many sessions will I need? 

Based on research it appears that 1-2 sessions per week over a period of 3-6 weeks is ideal, and we have tailored our program to fit this model. While some patients experience a rapid antidepressant effect immediately, it is common for this effect to wear off within days to weeks, and to need several sessions before feeling substantial relief. It is also common for patients to need maintenance therapy. Some find relief with sessions every 3-6 months, some shorter, some longer.


How do I know if ketamine is right for me?

Ketamine is not right for everyone. It is not a first-line treatment, and may exacerbate some mental health conditions, like bipolar disorder, schizophrenia, and some personality disorders. There are also some physical conditions (like uncontrolled high blood pressure) that may make ketamine treatment inappropriate. We offer a free 15 minute discovery call with one of our doctors to determine if ketamine may be a good fit for you. Schedule by calling (818) 794-6975.

How long is a session?

Ketamine sessions are scheduled for 120 minutes. This ensures we have enough time to check in prior to the treatment and process your experience so that you feel safe, cognizant and comfortable leaving the clinic.


Do you accept insurance?

We do not accept insurance for ketamine services, and payment is due prior or at the time of your visit. We strive to provide the best care for our patients, unfortunately that is not always synergistic with what is deemed necessary by insurance. We believe treatment choices should be decided between doctor and patient, not the insurance company. We can provide you will a superbill and you may receive reimbursement for some visits, but this is not a guarantee and is ultimately determined by your insurance provider.

Can I drive home after my session?

No. We require you to have a ride home on the days of ketamine treatment. Please arrange a family member or friend to drive you home, or you may use ride shares.


Read more about Ketamine Therapy

The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review

MAPS: Multidisciplinary Association for Psychedelic Studies

Ketmaine-Assisted Psychotherapy, Phil Wolfson, MD

The Scientific Evidence for Ketamine in Acute and Chronic Depression

Evolve Healthcare
20301 Ventura Boulevard, Suite 210
Los Angeles

Woodland Hills, CA 91364
Phone: 818-452-5312
Office Hours

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